Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ASPH | Q12797 | 2/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.38 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 5/20 | 0.37 |
| ▸ | LDHA | P00338 | 4/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16619487 | 0.90 | EGFR (0.39) | PRKDCEGFRTNFHDAC3HDAC1 | |
| SCHEMBL16618793 | 0.86 | ALDH1A1 (0.40) | KDM4EASPHKDM8RIOX2 | |
| SCHEMBL16618796 | 0.86 | ALDH1A1 (0.40) | KDM4EASPHKDM8RIOX2 | |
| SCHEMBL16619383 | 0.85 | PARP1 (0.43) | PRKDCEGFR | |
| SCHEMBL16619776 | 0.84 | KDM4E (0.47) | PRKDCEGFRTNFHDAC3HDAC1 | |
| SCHEMBL16619642 | 0.82 | EGFR (0.45) | PRKDCEGFRTNFLDHBLDHA | |
| SCHEMBL16619646 | 0.82 | EGFR (0.45) | PRKDCEGFRTNFLDHBLDHA | |
| SCHEMBL16619179 | 0.81 | EGFR (0.45) | PRKDCEGFRTNFPIK3CAPIK3CB | |
| SCHEMBL16619177 | 0.81 | EGFR (0.45) | PRKDCEGFRTNFPIK3CAPIK3CB | |
| SCHEMBL16618740 | 0.79 | EGFR (0.51) | PRKDCEGFRHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049629-A1 | IMIDAZOQUINOLINE COMPOUNDS AS BROMODOMAIN INHIBITORS | Piramal Enterprises Limited (IN) | 2015-04-09 | — | — | WO | disclosed |