Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ASPH | Q12797 | 2/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.36 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 2/20 | 0.36 |
| ▸ | LDHB | P07195 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16619383 | 0.92 | PARP1 (0.43) | EGFRPRKDC | |
| SCHEMBL16618978 | 0.90 | PRKDC (0.41) | EGFRPRKDCTNFHDAC3HDAC1 | |
| SCHEMBL16619354 | 0.87 | SIRT5 (0.39) | PLK1KDM4E | |
| SCHEMBL16619352 | 0.87 | SIRT5 (0.39) | PLK1KDM4E | |
| SCHEMBL16619179 | 0.83 | EGFR (0.45) | EGFRPRKDCTNF | |
| SCHEMBL16619177 | 0.83 | EGFR (0.45) | EGFRPRKDCTNF | |
| SCHEMBL16619776 | 0.83 | KDM4E (0.47) | EGFRPRKDCTNFHDAC3HDAC1 | |
| SCHEMBL16619646 | 0.80 | EGFR (0.45) | EGFRPRKDCPLK1TNFLDHA | |
| SCHEMBL16619642 | 0.80 | EGFR (0.45) | EGFRPRKDCPLK1TNFLDHA | |
| SCHEMBL16619018 | 0.79 | MAPT (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049629-A1 | IMIDAZOQUINOLINE COMPOUNDS AS BROMODOMAIN INHIBITORS | Piramal Enterprises Limited (IN) | 2015-04-09 | — | — | WO | disclosed |