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SCHEMBL16620583

SCHEMBL16620583

O=C(O)CN(CC(=O)O)CC(=O)NCC(=O)OCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 3/20 0.49
▸ CA2 P00918 3/20 0.49
▸ L3MBTL1 Q9Y468 2/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ MEN1 O00255 4/20 0.47
▸ KMT2A Q03164 4/20 0.47
▸ LMNA P02545 1/20 0.46
▸ GLA P06280 1/20 0.46
▸ CYP1A2 P05177 1/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ CYP2D6 P10635 1/20 0.45
▸ CYP2C9 P11712 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ ABCC3 O15438 1/20 0.45
▸ NR1I2 O75469 1/20 0.45
▸ ABCB11 O95342 1/20 0.45
▸ NR3C1 P04150 1/20 0.45
▸ RARG P13631 1/20 0.45
▸ CNR1 P21554 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16620889 0.86 HTT (0.48) CA1CA2L3MBTL1ALDH1A1MAPK1
SCHEMBL17879683 0.83 CA1 (0.66) CA1CA2L3MBTL1ALDH1A1MAPK1
SCHEMBL17879693 0.83 CA1 (0.66) CA1CA2L3MBTL1ALDH1A1MAPK1
SCHEMBL5555546 0.82 ALDH1A1 (0.54) L3MBTL1ALDH1A1MAPK1MEN1KMT2A
SCHEMBL10251482 0.82 EPHX2 (0.54) CA1CA2L3MBTL1ALDH1A1MEN1
SCHEMBL17883375 0.81 CA1 (0.48) CA1CA2L3MBTL1ALDH1A1MAPK1
SCHEMBL17883376 0.81 CA1 (0.53) CA1CA2L3MBTL1ALDH1A1MAPK1
SCHEMBL25681603 0.80 ALDH1A1 (0.56) L3MBTL1ALDH1A1MAPK1MEN1KMT2A
SCHEMBL22750096 0.80 SMN1; SMN2 (0.53) CA1CA2L3MBTL1ALDH1A1MAPK1
SCHEMBL5538472 0.79 L3MBTL1 (0.54) L3MBTL1ALDH1A1MAPK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12427187-B2 Glucose-responsive insulin conjugates MERCK SHARP & DOHME LLC (US) 2025-09-30 — — US disclosed
US-11413352-B2 Conjugate based systems for controlled insulin delivery Merck, Sharp & Dohme LLC (US) 2022-08-16 — — US disclosed
US-20220233647-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2022-07-28 — — US disclosed
EP-3980052-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2022-04-13 — — EP disclosed
US-20210177981-A1 CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY MERCK SHARP & DOHME CORP. (US) 2021-06-17 — — US disclosed
EP-3052134-B1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME (US) 2021-05-05 — — EP disclosed
WO-2020247297-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2020-12-10 — — WO disclosed
EP-3740212-A2 CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY Merck Sharp & Dohme Corp. (US) 2020-11-25 — — EP disclosed
CN-105792852-B Glucose-responsive insulin conjugates 默沙东公司 2019-12-10 — — CN disclosed
US-20180110863-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2018-04-26 — — US disclosed
EP-3280450-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES Merck Sharp & Dohme Corp. (US) 2018-02-14 — — EP disclosed
US-9889205-B2 Glucose-responsive insulin conjugates MERCK SHARP & DOHME CORP. (US) 2018-02-13 — — US disclosed
US-9884125-B2 Glucose-responsive insulin conjugates MERCK SHARP & DOHME CORP. (US) 2018-02-06 — — US disclosed
US-20160303244-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2016-10-20 — — US disclosed
WO-2016164288-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2016-10-13 — — WO disclosed
US-20160251407-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2016-09-01 — — US disclosed
US-9427475-B2 Glucose-responsive insulin conjugates MERCK SHARP & DOHME CORP. (US) 2016-08-30 — — US disclosed
EP-3052134-A2 GLUCOSE-RESPONSIVE INSULIN CONJUGATES Merck Sharp & Dohme Corp. (US) 2016-08-10 — — EP disclosed
US-20150105317-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME LLC 2015-04-16 — — US disclosed
WO-2015051052-A2 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2015-04-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210177981-A1 CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY GPR119, INSR, IGF1R CA1 1422/4885CA2 2637/4885L3MBTL1 1417/4885
US-12427187-B2 Glucose-responsive insulin conjugates GPR119, IRS1, INSR CA1 4443/4885CA2 4584/4885L3MBTL1 1420/4885
US-20180110863-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 CA1 1735/4885CA2 4534/4885L3MBTL1 1778/4885
US-20220233647-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, IRS1, INSR CA1 4443/4885CA2 4584/4885L3MBTL1 1420/4885
US-20150105317-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 CA1 2005/4885CA2 4528/4885L3MBTL1 1526/4885
US-11413352-B2 Conjugate based systems for controlled insulin delivery GPR119, INSR, IGF1R CA1 1422/4885CA2 2637/4885L3MBTL1 1417/4885
US-20160251407-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 CA1 2126/4885CA2 4612/4885L3MBTL1 1356/4885
US-20160303244-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 CA1 2005/4885CA2 4528/4885L3MBTL1 1526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.