SCHEMBL16622220

SCHEMBL16622220

CC(=O)Nc1cc(C#Cc2ccc(CC(N)=O)cc2)cnc1NC(C)=O

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 2/20 0.41
ACACB O00763 14/20 0.40
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1433492 0.88 EGLN1 (0.40) EGLN1ACACBKDM4EMEN1ALDH1A1
Hydrochloric Acid SCHEMBL1432970 0.87 EGLN1 (0.39) EGLN1ACACBKDM4EMEN1ALDH1A1
SCHEMBL16622211 0.82 KDM4E (0.45) ACACBKDM4EMEN1ALDH1A1HPGD
SCHEMBL27829450 0.82 EGLN1 (0.41) EGLN1ACACBKDM4EMEN1ALDH1A1
Hydrochloric Acid SCHEMBL27981488 0.81 EGLN1 (0.40) EGLN1ACACBKDM4EMEN1ALDH1A1
SCHEMBL16622225 0.80 PTK2 (0.46) ACACBKDM4EMEN1ALDH1A1HPGD
SCHEMBL16622212 0.76 KMT2A (0.69) EGLN1ACACBKDM4EMEN1ALDH1A1
SCHEMBL16622218 0.75 ACACB (0.43) ACACBKDM4EMEN1ALDH1A1HPGD
SCHEMBL16622216 0.73 IKBKB (0.52) ACACBKDM4EMEN1ALDH1A1HPGD
SCHEMBL1432853 0.70 SMN1; SMN2 (0.43) ACACBKDM4EMEN1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8999989-B2 Benzene or thiophene derivative and use thereof as VAP-1 inhibitor R-TECH UENO, LTD. (JP) 2015-04-07 US disclosed