Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17574065 | 0.86 | DGAT1 (0.44) | DGAT1 | |
| SCHEMBL20696336 | 0.83 | DGAT1 (0.35) | DGAT1 | |
| SCHEMBL8209867 | 0.77 | DGAT1 (0.38) | DGAT1 | |
| SCHEMBL16622303 | 0.77 | CA2 (0.35) | MMP8CA2HDAC3HDAC4HDAC1 | |
| SCHEMBL13640915 | 0.77 | CA2 (0.35) | MMP8CA2HDAC3HDAC4HDAC1 | |
| SCHEMBL18051751 | 0.77 | CA2 (0.38) | MMP8CA2HDAC3HDAC4HDAC1 | |
| SCHEMBL786780 | 0.77 | DGAT1 (0.41) | DGAT1 | |
| SCHEMBL20121856 | 0.76 | EGLN1 (0.42) | DGAT1 | |
| SCHEMBL23131222 | 0.76 | DGAT1 (0.37) | DGAT1 | |
| SCHEMBL22105978 | 0.76 | DGAT1 (0.58) | DGAT1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354265-A1 | TREATMENT OF SOLID TUMORS | President and Fellows of Harvard College (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-2491926-B1 | Treatment of protein degradation disorders | HARVARD COLLEGE (US) | 2018-05-09 | — | — | EP | disclosed |
| US-8999289-B2 | Treatment of protein degradation disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-04-07 | — | — | US | disclosed |