Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877799 | 0.90 | — | — | |
| SCHEMBL24000070 | 0.81 | — | — | |
| SCHEMBL13640915 | 0.81 | CA2 (0.35) | CA2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16523785 | 0.81 | TSHR (0.33) | — | |
| SCHEMBL12949585 | 0.80 | POLB (0.31) | — | |
| SCHEMBL18051751 | 0.80 | CA2 (0.38) | CA2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27267138 | 0.78 | ALDH1A1 (0.30) | — | |
| SCHEMBL20696336 | 0.77 | DGAT1 (0.35) | — | |
| SCHEMBL23641271 | 0.77 | — | — | |
| SCHEMBL16622294 | 0.77 | MMP8 (0.38) | CA2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354265-A1 | TREATMENT OF SOLID TUMORS | President and Fellows of Harvard College (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-2019674-B1 | HISTONE DEACETYLASE AND TUBULIN DEACETYLASE INHIBITORS | HARVARD COLLEGE (US) | 2016-11-23 | — | — | EP | disclosed |
| US-8999289-B2 | Treatment of protein degradation disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-04-07 | — | — | US | disclosed |