Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849249 | 0.87 | EGFR (0.40) | EGFRJAK2JAK1 | |
| SCHEMBL17849221 | 0.86 | EIF2AK2 (0.34) | EGFRJAK2JAK1PARP1 | |
| SCHEMBL17849188 | 0.85 | EGFR (0.40) | EGFRJAK2JAK1 | |
| SCHEMBL16623565 | 0.83 | ALDH1A1 (0.41) | — | |
| SCHEMBL18052623 | 0.82 | EGFR (0.36) | EGFRJAK2JAK1 | |
| SCHEMBL16623558 | 0.82 | PARP1 (0.34) | PARP1 | |
| SCHEMBL16623493 | 0.81 | TYK2 (0.39) | JAK2JAK1 | |
| SCHEMBL16623511 | 0.81 | TYK2 (0.38) | JAK2PARP1 | |
| SCHEMBL17849248 | 0.80 | EGFR (0.41) | EGFRJAK2JAK1 | |
| SCHEMBL16623568 | 0.80 | EGFR (0.38) | EGFRJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |