Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623495 | 0.86 | GHSR (0.36) | MAPTGHSRL3MBTL1KDM4EZAP70 | |
| SCHEMBL16623576 | 0.84 | HPGDS (0.35) | GHSRROCK1GSK3BUSP30KDM4E | |
| SCHEMBL17849223 | 0.75 | MAPT (0.41) | MAPTALDH1A1ROCK1HPGDLMNA | |
| SCHEMBL17849188 | 0.74 | EGFR (0.40) | MAPTALDH1A1ROCK1L3MBTL1ZAP70 | |
| SCHEMBL17849247 | 0.73 | MAPT (0.41) | MAPTALDH1A1GAAMAPK1TDP1 | |
| SCHEMBL17849227 | 0.70 | TYK2 (0.42) | ZAP70EGFRJAK3MAPK14 | |
| SCHEMBL17849222 | 0.70 | ALDH1A1 (0.36) | MAPTALDH1A1GAALMNATDP1 | |
| SCHEMBL16726651 | 0.69 | NPC1 (0.41) | ALDH1A1GAAGSK3BKDM4E | |
| SCHEMBL16623512 | 0.69 | JAK1 (0.43) | JAK3 | |
| SCHEMBL17849244 | 0.68 | TYK2 (0.40) | ALDH1A1HPGDKDM4EHSD17B10ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |