Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 6/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849188 | 0.81 | EGFR (0.40) | MAPTEGFRNPC1RAB9AMAPK14 | |
| SCHEMBL17849247 | 0.81 | MAPT (0.41) | MAPTEGFRNPC1MAPK1RAB9A | |
| SCHEMBL16726659 | 0.79 | JAK2 (0.34) | — | |
| SCHEMBL16623495 | 0.78 | GHSR (0.36) | MAPTEGFRMAPK14ZAP70KDM4E | |
| SCHEMBL17849227 | 0.78 | TYK2 (0.42) | EGFRMAPK14ZAP70HDAC3HDAC4 | |
| SCHEMBL16623576 | 0.77 | HPGDS (0.35) | EGFRMAPK14ZAP70GSK3BROCK1 | |
| SCHEMBL17849222 | 0.77 | ALDH1A1 (0.36) | MAPTLMNAEGFRNPC1RAB9A | |
| SCHEMBL17849244 | 0.76 | TYK2 (0.40) | EGFRMAPK14ALDH1A1ZAP70KDM4E | |
| SCHEMBL16623573 | 0.75 | MAPT (0.34) | MAPTLMNAEGFRMAPK1MAPK14 | |
| SCHEMBL17849249 | 0.71 | EGFR (0.40) | EGFRALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |