SCHEMBL16624349

SCHEMBL16624349

COC(=O)C(Cc1ccc(OCCCO[Si](C)(C)C(C)(C)C)cc1C)C(C)=O

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARG P37231 12/20 0.38
PPARD Q03181 8/20 0.38
PPARA Q07869 7/20 0.38
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PDIA6 Q15084 1/20 0.32
BTN3A1 O00481 1/20 0.32
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
P2RY12 Q9H244 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3706778 0.89 PPARG (0.38) PPARGPPARDPPARAALDH1A1TSHR
SCHEMBL16624370 0.78 PDIA6 (0.38) PPARGPPARDPPARAPDIA6
SCHEMBL3706808 0.76 MTNR1A (0.36) PPARGPPARAALDH1A1
SCHEMBL16624376 0.75 PDIA6 (0.38) PPARGPPARDPPARATSHRPDIA6
SCHEMBL4296678 0.74 PPARG (0.51) PPARGPPARDPPARA
SCHEMBL4296676 0.74 PPARG (0.51) PPARGPPARDPPARA
SCHEMBL8532125 0.72 PPARG (0.37) PPARGPPARDPPARAALDH1A1TSHR
SCHEMBL854714 0.72 DRD2 (0.34) PPARGPPARAALDH1A1
SCHEMBL16624375 0.71 MAPT (0.43) PPARGPPARDPPARATSHRTDP1
SCHEMBL15305570 0.70 PYCR1 (0.38) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160251319-A1 CARBOXYLIC ACID COMPOUNDS SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2016-09-01 US disclosed
US-9376398-B2 Carboxylic acid compounds SUMITOMO DAINIPPON PHARMA CO., LTD (JP) 2016-06-28 US disclosed
US-20150099770-A1 CARBOXYLIC ACID COMPOUNDS Sumitomo Pharma Co., Ltd. (JP) 2015-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150099770-A1 CARBOXYLIC ACID COMPOUNDS C9, SUCNR1, C3AR1 PPARG 272/4885PPARD 1098/4885PPARA 529/4885
US-20160251319-A1 CARBOXYLIC ACID COMPOUNDS C9, SUCNR1, C3AR1 PPARG 272/4885PPARD 1098/4885PPARA 529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.