Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801992 | 0.62 | LRRK2 (0.37) | SGK1HTR2AHTR2C | |
| SCHEMBL28340016 | 0.58 | CYP19A1 (0.41) | — | |
| SCHEMBL27164099 | 0.57 | SLC5A1 (0.38) | SLC5A1SLC5A2 | |
| SCHEMBL11833453 | 0.56 | CYP19A1 (0.39) | — | |
| SCHEMBL2153612 | 0.56 | CYP19A1 (0.48) | — | |
| SCHEMBL27164207 | 0.56 | ALDH1A1 (0.41) | — | |
| SCHEMBL11837367 | 0.56 | TSHR (0.41) | — | |
| SCHEMBL11844643 | 0.56 | IMPDH2 (0.41) | HTR2AHTR2C | |
| SCHEMBL27164067 | 0.55 | TSHR (0.39) | SLC5A1SLC5A2HTR2AHTR2C | |
| SCHEMBL11840566 | 0.55 | CYP19A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |