Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.35 |
| ▸ | IGFBP5 | P24593 | 2/20 | 0.32 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.30 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948656 | 0.75 | HCAR2 (0.49) | HCAR2RNASEH1 | |
| SCHEMBL27884838 | 0.69 | NPSR1 (0.44) | — | |
| SCHEMBL3690825 | 0.68 | ALOX15 (0.35) | HCAR2 | |
| SCHEMBL19780371 | 0.68 | KLKB1 (0.46) | — | |
| SCHEMBL22344571 | 0.67 | AKR1B1 (0.48) | — | |
| SCHEMBL1661165 | 0.67 | PTGER1 (0.41) | — | |
| SCHEMBL1661511 | 0.66 | TSHR (0.42) | — | |
| SCHEMBL3689833 | 0.66 | HCAR2 (0.41) | HCAR2 | |
| SCHEMBL1661713 | 0.66 | KDM4C (0.42) | — | |
| SCHEMBL948426 | 0.65 | RNASEH1 (0.49) | HCAR2RNASEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011524906-A | — | — | 2011-09-08 | — | — | JP | claimed |
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | claimed |