SCHEMBL16626502

SCHEMBL16626502

CNCc1cn(S(=O)(=O)c2cccc(OC)c2)c2cc(Nc3ccc(Cl)cc3C(F)(F)F)ccc12

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 14/20 0.42
SLC20A2 Q08357 1/20 0.39
SLC20A1 Q8WUM9 1/20 0.39
FBP1 P09467 3/20 0.38
PPARG P37231 2/20 0.35
PPARD Q03181 2/20 0.35
PPARA Q07869 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16618540 0.99 HTR6 (0.42) HTR6SLC20A2SLC20A1FBP1PPARG
SCHEMBL16626740 0.92 HTR6 (0.43) HTR6
SCHEMBL16626516 0.92 RORC (0.43) HTR6SLC20A2SLC20A1FBP1
Hydrochloric Acid SCHEMBL16618768 0.91 HTR6 (0.43) HTR6
Hydrochloric Acid SCHEMBL16618865 0.91 RORC (0.43) HTR6SLC20A2SLC20A1FBP1
SCHEMBL16626512 0.90 HTR6 (0.40) HTR6SLC20A2SLC20A1PPARG
Hydrochloric Acid SCHEMBL16619066 0.90 HTR6 (0.39) HTR6SLC20A2SLC20A1PPARG
SCHEMBL16626717 0.90 HTR6 (0.44) HTR6FBP1PPARGPPARDPPARA
Hydrochloric Acid SCHEMBL16618695 0.89 HTR6 (0.44) HTR6FBP1PPARGPPARDPPARA
SCHEMBL16626490 0.88 HTR6 (0.42) HTR6SLC20A2SLC20A1FBP1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP claimed
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed
US-9676714-B2 Sulfonylindole derivatives and method for preparing the same DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2017-06-13 US disclosed
US-9676714-B2 Sulfonylindole derivatives and method for preparing the same DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2017-06-13 US disclosed
US-20160221946-A1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2016-08-04 US disclosed
US-20160221946-A1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2016-08-04 US disclosed
WO-2015050412-A1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2015-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160221946-A1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME GIPR, PGC, SI HTR6 166/4885SLC20A2 2810/4885SLC20A1 2791/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.