Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623993 | 0.83 | THRB (0.33) | TSHRALDH1A1THRB | |
| SCHEMBL16623952 | 0.79 | GAA (0.35) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL16623954 | 0.79 | KDM4E (0.39) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL16623960 | 0.71 | GAA (0.34) | ALDH1A1 | |
| SCHEMBL16623964 | 0.70 | TSHR (0.41) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL16623966 | 0.69 | KDM4E (0.39) | TSHRALDH1A1 | |
| SCHEMBL69450 | 0.69 | TSHR (0.35) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL19518768 | 0.68 | TSHR (0.33) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL2721018 | 0.66 | TSHR (0.52) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL19376439 | 0.65 | TSHR (0.41) | TSHRHPGDALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052481-B1 | USE OF POLYMERIZABLE STABLE RADICALS FOR REDUCING THE SHRINKAGE STRESS OF DENTAL COMPOSITIONS | DENTSPLY SIRONA INC (US) | 2020-04-08 | — | — | EP | disclosed |
| US-9931280-B2 | Dental composite compositions for reduced shrinkage stress | DENTSPLY SIRONA INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | DENTSPLY SIRONA INC. | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | VCL, HSPA4L, GPX4 | TSHR 3714/4885HPGD 419/4885ALDH1A1 2471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.