Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25957083 | 0.78 | ALDH1A1 (0.39) | ALDH1A1CCR1CCR5CCR8PDGFRB | |
| SCHEMBL31278202 | 0.77 | MAOA (0.42) | MAOAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL4080571 | 0.77 | MAOA (0.42) | MAOAPDE2APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL27652560 | 0.76 | MAOA (0.46) | MAOAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL31147147 | 0.76 | MAOA (0.41) | MAOAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL3979208 | 0.76 | MAOA (0.50) | MAOAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL24344928 | 0.74 | MAOA (0.40) | MAOAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL8198856 | 0.74 | KDM4E (0.45) | MAOAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL14353296 | 0.74 | IKBKB (0.41) | MAOAPDE2APDE4APDE4BPDE4C | |
| SCHEMBL23624591 | 0.74 | MAOA (0.40) | MAOAPDE2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051043-A1 | BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2015-04-09 | — | — | WO | disclosed |