Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2748297 | 0.82 | MEN1 (0.51) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL21900500 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL16621363 | 0.81 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL16628134 | 0.80 | KCNA3 (0.47) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL2747983 | 0.79 | SLC6A4 (0.46) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL2747984 | 0.79 | SLC6A4 (0.46) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL4071443 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL2387597 | 0.76 | PKM (0.53) | ALDH1A1MEN1KMT2AL3MBTL1EPHX2 | |
| SCHEMBL2748689 | 0.75 | MEN1 (0.50) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL7732958 | 0.75 | L3MBTL1 (0.57) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |