Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.47 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628262 | 0.83 | NPC1 (0.47) | LMNAP2RX7MEN1KMT2AAURKA | |
| SCHEMBL16628330 | 0.82 | CHRM1 (0.43) | HTTP2RX7MEN1KMT2ARPS6KB1 | |
| SCHEMBL19997558 | 0.82 | LMNA (0.53) | LMNAHTTP2RX7GPR52MEN1 | |
| SCHEMBL21043124 | 0.82 | GRK2 (0.42) | LMNAHTTP2RX7DBHROCK2 | |
| SCHEMBL22001747 | 0.81 | CHRM1 (0.57) | — | |
| SCHEMBL21043125 | 0.81 | CHRM1 (0.57) | — | |
| SCHEMBL16593395 | 0.81 | CHRM1 (0.57) | — | |
| SCHEMBL21043062 | 0.80 | NNMT (0.42) | P2RX7GPR52 | |
| SCHEMBL19997529 | 0.79 | ADRA1D (0.48) | LMNAP2RX7AKT1SMN1; SMN2 | |
| SCHEMBL16593451 | 0.79 | CHRM1 (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |