Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SCD | O00767 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19997529 | 0.89 | ADRA1D (0.48) | CHRM1SMN1; SMN2SCDP2RX7TP53 | |
| SCHEMBL21043053 | 0.88 | CHRM1 (0.43) | CHRM1L3MBTL1SMN1; SMN2SCDP2RX7 | |
| SCHEMBL21042584 | 0.87 | POLB (0.42) | POLBRPS6KB1SOS1RXFP1MAPK14 | |
| SCHEMBL19997556 | 0.86 | RPS6KB1 (0.42) | POLBRPS6KB1MAPK14L3MBTL1GRM2 | |
| SCHEMBL16628262 | 0.86 | NPC1 (0.47) | CHRM1POLBRPS6KB1L3MBTL1MEN1 | |
| SCHEMBL21043057 | 0.85 | LMNA (0.47) | CHRM1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL16628266 | 0.82 | LMNA (0.49) | RPS6KB1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21043062 | 0.81 | NNMT (0.42) | CHRM1GRM2P2RX7 | |
| SCHEMBL22001366 | 0.79 | ALDH1A1 (0.48) | SOS1RXFP1L3MBTL1MEN1KMT2A | |
| SCHEMBL16593207 | 0.78 | CHRM1 (0.59) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |
| US-9926312-B2 | 4-azaindole derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-03-27 | — | — | US | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |