Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | PDE6A | P16499 | 1/20 | 0.38 |
| ▸ | PDE6G | P18545 | 1/20 | 0.38 |
| ▸ | PDE6B | P35913 | 1/20 | 0.38 |
| ▸ | PDE6C | P51160 | 1/20 | 0.38 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628264 | 0.91 | CHRM1 (0.47) | NPC1RAB9ANOD2HTR6CHRM1 | |
| SCHEMBL16628257 | 0.87 | NPC1 (0.58) | NPC1RAB9ANOD2CHRM1ATM | |
| SCHEMBL16628263 | 0.83 | POLB (0.56) | CHRM1RPS6KB1POLBGRM2 | |
| SCHEMBL16628328 | 0.82 | RPS6KB1 (0.54) | HTR6CHRM1RPS6KB1LMNAPOLB | |
| SCHEMBL22001276 | 0.82 | ALDH1A1 (0.49) | NPC1RAB9ANOD2HTR6CHRM1 | |
| SCHEMBL21043084 | 0.82 | NPC1 (0.47) | NPC1RAB9ANOD2HTR6CHRM1 | |
| SCHEMBL19997523 | 0.82 | CHRM1 (0.48) | NPC1RAB9ANOD2HTR6CHRM1 | |
| SCHEMBL22001750 | 0.81 | RAB9A (0.54) | NPC1RAB9ANOD2HTR6CHRM1 | |
| SCHEMBL22001753 | 0.80 | POLB (0.53) | CHRM1RPS6KB1POLBGRM2 | |
| SCHEMBL16539026 | 0.80 | BRD4 (0.43) | NPC1RAB9ANOD2CHRM1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |