Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628263 | 0.86 | POLB (0.56) | RPS6KB1ALDH1A1SMN1; SMN2HTTCHRM1 | |
| SCHEMBL22001753 | 0.83 | POLB (0.53) | RPS6KB1ALDH1A1SMN1; SMN2HTTCHRM1 | |
| SCHEMBL16628329 | 0.83 | CHRM1 (0.44) | RPS6KB1CHRM1GRM2POLBPARP1 | |
| SCHEMBL16628334 | 0.82 | NPC1 (0.44) | RPS6KB1LMNAHTR6CHRM1GRM2 | |
| SCHEMBL16628264 | 0.82 | CHRM1 (0.47) | RPS6KB1HTR6CHRM1AURKAAURKB | |
| SCHEMBL21043130 | 0.82 | ALDH1A1 (0.66) | LMNAALDH1A1TDP1SMN1; SMN2HTT | |
| SCHEMBL18011014 | 0.81 | CHRM1 (0.43) | CHRM1PARP1 | |
| SCHEMBL19997558 | 0.80 | LMNA (0.53) | LMNAHTTCHRM1ROCK2 | |
| SCHEMBL16628259 | 0.80 | ADRA1D (0.50) | HTTNPSR1CHRM1 | |
| SCHEMBL21043461 | 0.80 | POLB (0.54) | L3MBTL1CHRM1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |