Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22001753 | 0.96 | POLB (0.53) | POLBRPS6KB1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16593276 | 0.90 | POLB (0.56) | POLBALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL21043066 | 0.89 | POLB (0.69) | POLBALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL16628259 | 0.88 | ADRA1D (0.50) | HTTMAPTCHRM1CNR2 | |
| SCHEMBL16628328 | 0.86 | RPS6KB1 (0.54) | POLBRPS6KB1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL22001174 | 0.85 | CHRM1 (0.56) | POLBALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL16593303 | 0.84 | POLB (0.51) | POLBALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL16628324 | 0.84 | CHRM1 (0.68) | CHRM1 | |
| SCHEMBL16628329 | 0.83 | CHRM1 (0.44) | POLBRPS6KB1CHRM1GRM2 | |
| SCHEMBL16628334 | 0.83 | NPC1 (0.44) | POLBRPS6KB1CHRM1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |