Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 5/20 | 0.38 |
| ▸ | PDE1A | P54750 | 4/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.36 |
| ▸ | PDE8A | O60658 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | PDE6A | P16499 | 1/20 | 0.36 |
| ▸ | PDE6G | P18545 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE6B | P35913 | 1/20 | 0.36 |
| ▸ | PDE6C | P51160 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591359 | 0.85 | L3MBTL1 (0.43) | PDE9AKMT2AMEN1POLBPDE10A | |
| SCHEMBL972907 | 0.81 | CSF1R (0.43) | PDE9AKMT2AMEN1POLBPDE10A | |
| SCHEMBL970128 | 0.81 | OPRM1 (0.46) | PDE9AKMT2AMEN1POLBPDE10A | |
| SCHEMBL17505337 | 0.81 | PDE9A (0.56) | PDE9APDE5AKDM4EALDH1A1HPGD | |
| SCHEMBL3595821 | 0.81 | ALDH1A1 (0.43) | PDE9AKMT2AMEN1POLBPDE10A | |
| SCHEMBL17505336 | 0.80 | PDE9A (0.55) | PDE9APDE5A | |
| SCHEMBL3598763 | 0.78 | PDE9A (0.57) | PDE9AKMT2AMEN1POLBPDE10A | |
| SCHEMBL11997315 | 0.77 | ALDH1A1 (0.42) | PDE9AKMT2APDE7AKDM4EALDH1A1 | |
| SCHEMBL3595214 | 0.76 | TLR8 (0.42) | PDE9AKMT2AMEN1POLBPDE10A | |
| SCHEMBL3591867 | 0.75 | PDE9A (0.56) | PDE9AKMT2AMEN1POLBPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489667-B1 | Quinoxaline derivative | ASKA PHARM CO LTD (JP) | 2015-04-15 | — | — | EP | claimed |