Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31384301 | 0.85 | KDM4E (0.61) | POLBSMPD1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL165878 | 0.85 | POLB (0.76) | POLBSMPD1ALDH1A1LMNARAB9A | |
| SCHEMBL30949366 | 0.84 | POLB (0.74) | POLBSMPD1ALDH1A1LMNARAB9A | |
| SCHEMBL3748633 | 0.83 | PTPN1 (0.65) | POLBALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27851472 | 0.83 | MAPK1 (0.69) | POLBSMPD1ALDH1A1LMNARAB9A | |
| SCHEMBL31384359 | 0.82 | PKM (0.59) | POLBALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL31384308 | 0.82 | NOTUM (0.61) | POLBALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL326606 | 0.81 | PTPN1 (0.72) | POLBSMPD1ALDH1A1LMNARAB9A | |
| SCHEMBL3823166 | 0.80 | SMPD1 (0.65) | POLBSMPD1ALDH1A1LMNARAB9A | |
| SCHEMBL17377393 | 0.80 | PTPN1 (0.70) | POLBSMPD1ALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119504731-A | Naringenin derivative containing 1,3, 4-oxadiazole acylhydrazone structure and preparation method thereof | 广东省科学院测试分析研究所(中国广州分析测试中心) | 2025-02-25 | — | — | CN | disclosed |
| EP-2424870-B1 | Therapeutic agents 713 | ASTRAZENECA AB (SE) | 2015-12-16 | — | — | EP | disclosed |
| EP-2424870-A1 | THERAPEUTIC AGENTS 713 | AstraZeneca AB (SE) | 2012-03-07 | — | — | EP | disclosed |
| US-8110566-B2 | Therapeutic agents 713 | ASTRAZENECA AB (SE) | 2012-02-07 | — | — | US | disclosed |
| WO-2010125390-A1 | THERAPEUTIC AGENTS 713 | ASTRAZENECA AB (SE) | 2010-11-04 | — | — | WO | disclosed |
| US-20100280000-A1 | THERAPEUTIC AGENTS 713 | ASTRAZENECA AB (SE) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280000-A1 | THERAPEUTIC AGENTS 713 | MC1R, MC2R, MC3R | POLB 3052/4885SMPD1 858/4885ALDH1A1 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.