Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015825 | 0.83 | MAPT (0.55) | TAAR1SLC6A4SLC6A2SLC6A3GABRA1 | |
| SCHEMBL104467 | 0.82 | TAAR1 (0.74) | TAAR1SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL28161128 | 0.80 | CTSS (0.48) | TAAR1SLC6A4SLC6A2SLC6A3GABRA1 | |
| SCHEMBL16675752 | 0.80 | FYN (0.59) | GABRA1GABRB2CYP2D6PTPRCCYP3A4 | |
| SCHEMBL2929152 | 0.80 | CALM1 (0.46) | GABRA1GABRB2CYP2D6PTPRCCYP3A4 | |
| SCHEMBL18014706 | 0.79 | GABRA1 (0.45) | TAAR1SLC6A4SLC6A2SLC6A3GABRA1 | |
| SCHEMBL2692579 | 0.78 | CA12 (0.59) | GABRA1GABRB2PTPRCCYP3A4NPC1 | |
| SCHEMBL29629010 | 0.78 | PTGS2 (0.58) | GABRA1GABRB2PTPRCCYP3A4NPC1 | |
| SCHEMBL8636391 | 0.77 | MEN1 (0.46) | TAAR1SLC6A4SLC6A2SLC6A3GABRA1 | |
| SCHEMBL14200080 | 0.76 | GABRA1 (0.55) | TAAR1SLC6A4SLC6A2SLC6A3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049616-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2015-04-09 | — | — | WO | disclosed |