Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537183 | 0.89 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL29507776 | 0.88 | NR1H2 (0.54) | P2RX7NR1H2HRH3GPR119ESR2 | |
| SCHEMBL22650493 | 0.88 | NR1H2 (0.54) | P2RX7NR1H2HRH3GPR119ESR2 | |
| SCHEMBL2366725 | 0.88 | NR1H2 (0.44) | P2RX7NR1H2LMNATP53MAPT | |
| SCHEMBL1584703 | 0.86 | CPS1 (0.46) | P2RX7NR1H2MAPTHRH3GPR119 | |
| SCHEMBL28692485 | 0.85 | ALDH1A1 (0.54) | P2RX7LMNAMAPTTHRB | |
| SCHEMBL1583488 | 0.84 | MEN1 (0.51) | P2RX7NR1H2TP53MAPTTHRB | |
| SCHEMBL30734152 | 0.84 | MEN1 (0.51) | P2RX7NR1H2TP53MAPTTHRB | |
| SCHEMBL3929365 | 0.83 | L3MBTL1 (0.55) | LMNATP53MAPTTHRBGPR119 | |
| SCHEMBL1662961 | 0.81 | P2RX7 (0.42) | P2RX7LMNAMAPTGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050284-A1 | PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |