Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1583488 | 1.00 | MEN1 (0.51) | MEN1KMT2ASCN9ASCN5AGRM5 | |
| SCHEMBL7535800 | 0.86 | SMARCA2 (0.49) | MAPK1P2RX7MAPTSMN1; SMN2NR1H2 | |
| SCHEMBL3653185 | 0.86 | P2RX7 (0.55) | GRM5GRM1MAPK1P2RX7MAPT | |
| SCHEMBL2889747 | 0.85 | SCN9A (0.49) | MEN1KMT2ASCN9ASCN5AGRM5 | |
| SCHEMBL4537183 | 0.85 | P2RX7 (0.55) | P2RX7SMN1; SMN2 | |
| SCHEMBL1663013 | 0.85 | P2RX7 (0.56) | MEN1KMT2AMAPK1P2RX7 | |
| SCHEMBL29507776 | 0.84 | NR1H2 (0.54) | P2RX7SMN1; SMN2NR1H2 | |
| SCHEMBL22650493 | 0.84 | NR1H2 (0.54) | P2RX7SMN1; SMN2NR1H2 | |
| SCHEMBL1662960 | 0.84 | P2RX7 (0.44) | TP53THRBP2RX7MAPTNR1H2 | |
| SCHEMBL1663068 | 0.83 | GRM5 (0.51) | SCN9ASCN5AGRM5GRM1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543888-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | Arizona Board of Regents on behalf of The University of Arizona (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250083-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2023-12-28 | — | — | WO | disclosed |