Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.42 |
| ▸ | CETP | P11597 | 3/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17986544 | 0.89 | GPR119 (0.39) | GPR119CETPNSD2LIMK2PDK1 | |
| SCHEMBL17986542 | 0.89 | GPR119 (0.39) | GPR119CETPNSD2LIMK2PDK1 | |
| SCHEMBL16620144 | 0.89 | GPR119 (0.39) | GPR119CETPNSD2LIMK2PDK1 | |
| SCHEMBL16630218 | 0.89 | CETP (0.37) | GPR119CETPLIMK2MEN1KMT2A | |
| SCHEMBL16629828 | 0.89 | CETP (0.38) | GPR119CETPLIMK2SLC2A1MEN1 | |
| SCHEMBL16629823 | 0.88 | CETP (0.36) | GPR119CETPLIMK2SLC2A1MEN1 | |
| SCHEMBL21278650 | 0.85 | GPR119 (0.41) | GPR119CETPLIMK2 | |
| SCHEMBL16629921 | 0.84 | CETP (0.38) | GPR119CETPLIMK2MEN1KMT2A | |
| SCHEMBL16630588 | 0.83 | ACACB (0.40) | GPR119PDK1MEN1KMT2A | |
| SCHEMBL16629818 | 0.81 | GPR119 (0.37) | GPR119NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050798-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-04-09 | — | — | WO | disclosed |