Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DTYMK | P23919 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30734152 | 0.83 | MEN1 (0.51) | GRM5GRM1MAPK1NR1H2SCN9A | |
| SCHEMBL1583488 | 0.83 | MEN1 (0.51) | GRM5GRM1MAPK1NR1H2SCN9A | |
| SCHEMBL11356927 | 0.82 | HRH3 (0.56) | GRM5GRM1POLBHRH3GPR119 | |
| SCHEMBL868914 | 0.82 | GPR119 (0.54) | GRM5POLBDTYMKGPR119MAPK1 | |
| SCHEMBL1666309 | 0.81 | HRH3 (0.45) | POLBHRH3GPR119SCN9A | |
| SCHEMBL1583147 | 0.80 | GPR119 (0.58) | GRM5GRM1POLBDTYMKGPR119 | |
| SCHEMBL2889747 | 0.77 | SCN9A (0.49) | GRM5GRM1GPR119MAPK1P2RX3 | |
| SCHEMBL28597591 | 0.77 | GPR119 (0.58) | GRM5GRM1POLBDTYMKGPR119 | |
| SCHEMBL4537183 | 0.77 | P2RX7 (0.55) | — | |
| SCHEMBL1662960 | 0.76 | P2RX7 (0.44) | HRH3GPR119NR1H2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050284-A1 | PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |