Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 8/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16633077 | 0.86 | RORC (0.49) | RORCHPGD | |
| SCHEMBL18725940 | 0.80 | KDM4E (0.50) | KDM4EMEN1KMT2ARORC | |
| SCHEMBL16479373 | 0.78 | ESR1 (0.43) | KDM4EMEN1KMT2ARORC | |
| SCHEMBL21538899 | 0.78 | RORC (0.33) | KDM4EMEN1KMT2ARORC | |
| SCHEMBL16641807 | 0.77 | RORC (0.59) | RORC | |
| SCHEMBL15647610 | 0.75 | KMT2A (0.53) | KDM4EMEN1KMT2ARORC | |
| SCHEMBL6862382 | 0.69 | PIK3CA (0.51) | CNR1HPGD | |
| SCHEMBL16632007 | 0.68 | RORC (0.77) | RORC | |
| SCHEMBL16460233 | 0.68 | RORC (0.56) | RORC | |
| SCHEMBL16632803 | 0.67 | RORC (0.59) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3560920-A1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T | Janssen Pharmaceutica NV (BE) | 2019-10-30 | — | — | EP | disclosed |
| EP-3560920-A1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T | Janssen Pharmaceutica NV (BE) | 2019-10-30 | — | — | EP | disclosed |
| EP-3057949-B1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-05 | — | — | EP | disclosed |
| EP-3057949-B1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-05 | — | — | EP | disclosed |
| US-9221804-B2 | Secondary alcohol quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-29 | — | — | US | disclosed |
| US-9221804-B2 | Secondary alcohol quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-29 | — | — | US | disclosed |
| US-9221804-B2 | Secondary alcohol quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-29 | — | — | US | disclosed |
| US-20150105372-A1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
| US-20150105372-A1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
| US-20150105372-A1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105372-A1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | KDM4E 2104/4885MEN1 4314/4885KMT2A 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.