Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634750 | 0.75 | PARP1 (0.44) | AURKAKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL16634673 | 0.74 | RORC (0.40) | — | |
| SCHEMBL6840347 | 0.72 | AURKA (0.64) | AURKAKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL702708 | 0.71 | AURKA (0.54) | AURKAKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL11472934 | 0.71 | LCK (0.52) | KMT2AMEN1ALDH1A1POLBLCK | |
| SCHEMBL6840348 | 0.71 | KMT2A (0.53) | AURKAKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL20302464 | 0.71 | L3MBTL1 (0.46) | AURKAKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL16634744 | 0.70 | L3MBTL1 (0.55) | AURKAKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL16634743 | 0.69 | AURKA (0.44) | AURKAKMT2AMEN1L3MBTL1CSNK2A1 | |
| SCHEMBL16634668 | 0.68 | KMT2A (0.45) | AURKAKMT2AMEN1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |