Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 19/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634751 | 0.79 | RORC (0.42) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634671 | 0.79 | LTA4H (0.39) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634554 | 0.78 | RORC (0.55) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634649 | 0.78 | RORC (0.43) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634779 | 0.74 | RORC (0.53) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634679 | 0.74 | RORC (0.46) | RORCCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL16634530 | 0.74 | AURKA (0.40) | — | |
| SCHEMBL16634636 | 0.71 | RORC (0.56) | RORCCYP2C9CYP3A4CYP2C19PPARG | |
| SCHEMBL16634721 | 0.69 | RAB9A (0.45) | RORC | |
| SCHEMBL16634830 | 0.68 | RORC (0.43) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | claimed |
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |