Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707730 | 0.79 | EGFR (0.66) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL1706614 | 0.78 | TYK2 (0.67) | — | |
| SCHEMBL18375950 | 0.78 | ALDH1A1 (0.67) | SMN1; SMN2RAB9ANPC1GAAMAPT | |
| SCHEMBL3515174 | 0.78 | PDPK1 (0.52) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL6900575 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANPC1GAAMAPT | |
| SCHEMBL4122902 | 0.77 | TRPV1 (0.65) | SMN1; SMN2RAB9ANPC1GAAMAPT | |
| SCHEMBL4778970 | 0.75 | SMN1; SMN2 (0.71) | SMN1; SMN2RAB9ANPC1GAAMAPT | |
| SCHEMBL2255472 | 0.75 | MAPK13 (0.60) | SMN1; SMN2RAB9ANPC1GAAMAPT | |
| SCHEMBL2685930 | 0.74 | CDC25B (0.71) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL3627660 | 0.74 | MAPT (0.62) | SMN1; SMN2RAB9ANPC1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |