Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634719 | 0.83 | AURKA (0.37) | FGFR1FGFR2FGFR3CACNA1HCACNA1G | |
| SCHEMBL16634807 | 0.79 | CACNA1H (0.34) | FGFR1FGFR2FGFR3CACNA1HCACNA1G | |
| SCHEMBL16634795 | 0.67 | DAO (0.44) | HSP90AA1 | |
| SCHEMBL13340811 | 0.60 | HIF1A (0.42) | CACNA1HCACNA1GCACNA1IFFAR1ACACB | |
| SCHEMBL15262867 | 0.59 | PLA2G2A (0.43) | CACNA1HCACNA1GCACNA1IFFAR1MEN1 | |
| SCHEMBL9935890 | 0.59 | ACACB (0.50) | CACNA1HCACNA1GCACNA1IFFAR1ACACB | |
| SCHEMBL21447017 | 0.59 | ACACB (0.43) | FGFR1FGFR2FGFR3CACNA1HCACNA1G | |
| SCHEMBL13859582 | 0.59 | CACNA1H (0.39) | CACNA1HCACNA1GCACNA1IFFAR1ACACB | |
| SCHEMBL24485425 | 0.59 | SLC26A4 (0.58) | MEN1MAPTTSHRBLMKMT2A | |
| SCHEMBL29629701 | 0.59 | SLC26A4 (0.58) | MEN1MAPTTSHRBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |