Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634807 | 0.89 | CACNA1H (0.34) | CACNA1HCACNA1GCACNA1IFGFR1FGFR2 | |
| SCHEMBL16634808 | 0.83 | FGFR1 (0.35) | CACNA1HCACNA1GCACNA1IFGFR1FGFR2 | |
| SCHEMBL16634654 | 0.72 | GAA (0.44) | CACNA1HCACNA1GCACNA1ISMN1; SMN2KDM4E | |
| SCHEMBL16634645 | 0.72 | RORC (0.45) | — | |
| SCHEMBL16634626 | 0.71 | HSP90AA1 (0.54) | AURKASMN1; SMN2KDM4EB3GNT2 | |
| SCHEMBL5095969 | 0.71 | ACACB (0.50) | SMN1; SMN2NPC1POLBTSHRHSD17B10 | |
| SCHEMBL16634859 | 0.70 | AURKA (0.44) | AURKASMN1; SMN2KDM4EMEN1TSHR | |
| SCHEMBL16634547 | 0.70 | MAPT (0.48) | SMN1; SMN2MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL16634544 | 0.70 | MAPT (0.48) | SMN1; SMN2MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL16634651 | 0.68 | CREBBP (0.42) | AURKASMN1; SMN2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |