Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661454 | 0.88 | CHRM1 (0.64) | CHRM1KDM4EAPEX1PRKAG1PRKAA2 | |
| Procodazole SCHEMBL838841 | 0.78 | CHRM1 (1.00) | CHRM1KDM4EAPEX1PRKAG1PRKAA2 | |
| Procodazole SCHEMBL349966 | 0.78 | CHRM1 (1.00) | CHRM1KDM4EAPEX1PRKAG1PRKAA2 | |
| Procodazole SCHEMBL29404024 | 0.78 | CHRM1 (1.00) | CHRM1KDM4EAPEX1PRKAG1PRKAA2 | |
| SCHEMBL699318 | 0.78 | RAB9A (0.67) | CHRM1ALDH1A1MAPTGAAPOLB | |
| SCHEMBL2565679 | 0.78 | MAOB (0.43) | CHRM1KDM4EALDH1A1MAPT | |
| Procodazole SCHEMBL5413283 | 0.75 | CHRM1 (0.91) | CHRM1KDM4EAPEX1PRKAG1PRKAA2 | |
| SCHEMBL19330024 | 0.74 | DDAH1 (0.58) | GAAPOLBPKM | |
| SCHEMBL1662293 | 0.74 | CYP1A2 (0.41) | CHRM1KDM4EAPEX1PRKAG1PRKAA2 | |
| SCHEMBL11217654 | 0.73 | PRKAG1 (0.69) | CHRM1KDM4EAPEX1PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |