Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16644311 | 0.80 | ALDH1A1 (0.59) | HPGDALDH1A1 | |
| SCHEMBL16637181 | 0.79 | HPGD (0.52) | HPGDALDH1A1TDP1GAAMEN1 | |
| SCHEMBL16637329 | 0.76 | OPRM1 (0.41) | HPGDALDH1A1GAASMN1; SMN2 | |
| SCHEMBL27479149 | 0.72 | HPGD (1.00) | HPGDALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL7132525 | 0.72 | HPGD (1.00) | HPGDALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL16361765 | 0.72 | TP53 (0.44) | GAATSHRLMNAHTTSMN1; SMN2 | |
| SCHEMBL10721733 | 0.71 | HPGD (0.95) | HPGDALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL1360270 | 0.70 | HPGD (0.92) | HPGDALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL1358720 | 0.70 | HPGD (0.65) | HPGDALDH1A1TDP1GAAMEN1 | |
| SCHEMBL16637299 | 0.69 | POLB (0.45) | TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105324382-B | Spirocyclic derivatives, its preparation method and the application of the ketone of 4,5 dihydro-pyrazolos [3,4 c] pyridine 2 | 四川海思科制药有限公司 | 2017-11-10 | — | — | CN | disclosed |
| CN-105324382-A | 4,5-dihydro-pyrazolo[3,4-c]pyridin-2-one spiro derivative, preparation method and use thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-02-10 | — | — | CN | disclosed |
| WO-2015051713-A1 | 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRIDIN-2-ONE SPIRO DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 | 2015-04-16 | — | — | WO | disclosed |
| WO-2015051713-A1 | 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRIDIN-2-ONE SPIRO DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 | 2015-04-16 | — | — | WO | disclosed |