Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 2/20 | 0.31 |
| ▸ | EDNRA | P25101 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637942 | 0.80 | KDM4E (0.35) | POLBFFAR4TSHRHSD17B10CASP1 | |
| SCHEMBL30195988 | 0.80 | ALDH1A1 (0.38) | POLBTSHRHSD17B10CASP1CASP7 | |
| SCHEMBL29288404 | 0.79 | LMNA (0.35) | POLBTSHRHSD17B10CASP1CASP7 | |
| SCHEMBL3339137 | 0.76 | HSD17B10 (0.39) | POLBFFAR4TSHRHSD17B10ALDH1A1 | |
| SCHEMBL8215092 | 0.76 | CA2 (0.42) | POLBSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL31124728 | 0.75 | POLB (0.33) | POLBTSHRHSD17B10CASP1CASP7 | |
| SCHEMBL30512208 | 0.74 | CYP1A1 (0.37) | ALDH1A1F2MAPTLMNA | |
| Ammonia Solution, Strong SCHEMBL28142626 | 0.74 | HSD17B10 (0.38) | POLBTSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL25311261 | 0.73 | PTGER1 (0.39) | TSHRHSD17B10CASP1CASP7SMN1; SMN2 | |
| SCHEMBL16039242 | 0.72 | MAPT (0.41) | POLBTSHRALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055288-A1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015051725-A1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |