Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.87 |
| ▸ | TP53 | P04637 | 2/20 | 0.87 |
| ▸ | HPGD | P15428 | 2/20 | 0.87 |
| ▸ | TSHR | P16473 | 2/20 | 0.87 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9139821 | 0.93 | ALDH1A1 (1.00) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL11292115 | 0.93 | TSHR (0.74) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL9831538 | 0.91 | LMNA (0.71) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL7107070 | 0.89 | LMNA (0.69) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL17367963 | 0.87 | ALDH1A1 (0.87) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL9671967 | 0.87 | ALDH1A1 (0.87) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL1007130 | 0.83 | ALDH1A1 (0.73) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL7148358 | 0.82 | ALDH1A1 (0.58) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL7152871 | 0.82 | ALDH1A1 (0.78) | LMNAALDH1A1HSD17B10TP53HPGD | |
| SCHEMBL8106730 | 0.81 | KDM4E (0.86) | LMNAALDH1A1HSD17B10TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311806-A2 | Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists | The United States of America, Represented by the Secretary, Department of Health and Human Services (US) | 2011-04-20 | — | — | EP | disclosed |
| US-6066642-A | FOR SELECTIVELY BLOCKING THE A3 ADENOSINE RECEPTOR OF A MAMMAL | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-05-23 | — | — | US | disclosed |