Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24802600 | 0.82 | ADORA3 (0.56) | ADORA3KDM4EGAAGDAPOLB | |
| SCHEMBL15325124 | 0.76 | GDA (0.43) | ADORA3KDM4EGAAGDAPOLB | |
| SCHEMBL16513138 | 0.71 | KDM4E (0.55) | ADORA3KDM4EGAAGDAPOLB | |
| SCHEMBL16513137 | 0.70 | GDA (0.64) | ADORA3KDM4EGAAGDAPOLB | |
| SCHEMBL11561386 | 0.70 | L3MBTL1 (0.51) | ADORA3KDM4EPOLBALDH1A1ALOX15 | |
| SCHEMBL28830993 | 0.70 | L3MBTL1 (0.43) | ADORA3GAAPOLBALDH1A1TDP1 | |
| SCHEMBL3605662 | 0.69 | KDM4E (0.49) | ADORA3KDM4EGAAGDAPOLB | |
| SCHEMBL11837884 | 0.68 | POLB (0.48) | ADORA3KDM4EGAAGDAPOLB | |
| SCHEMBL216305 | 0.68 | ALDH1A1 (0.48) | ADORA3KDM4EGAAGDAPOLB | |
| SCHEMBL4069624 | 0.68 | POLB (0.48) | ADORA3KDM4EGAAGDAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371326-B2 | Method for synthesizing sapropterin dihydrochloride | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2016-06-21 | — | — | US | disclosed |
| US-9365573-B2 | Method for synthesizing sapropterin dihydrochloride | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2016-06-14 | — | — | US | disclosed |
| US-20150119573-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD (CN) | 2015-04-30 | — | — | US | disclosed |
| US-20150105555-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD (CN) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105555-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | CYP51A1, DHCR7, LSS | ADORA3 3334/4885KDM4E 4409/4885GAA 3185/4885 |
| US-20150119573-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | DHCR7, CYP51A1, HMGCR | ADORA3 1512/4885KDM4E 4609/4885GAA 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.