Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.53 |
| ▸ | POLB | P06746 | 12/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 11/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.51 |
| ▸ | RECQL | P46063 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.51 |
| ▸ | EIF4E | P06730 | 1/20 | 0.51 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.51 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | APEX1 | P27695 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17789559 | 0.91 | ALDH1A1 (0.53) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL16687570 | 0.87 | KDM4E (0.58) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL16639748 | 0.84 | MAPT (0.43) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL14291851 | 0.80 | KMT2A (0.50) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL16639743 | 0.78 | DUSP3 (0.56) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL17789560 | 0.78 | ENPP2 (0.60) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL16639749 | 0.77 | KMT2A (0.72) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL23692381 | 0.75 | MAP3K5 (0.45) | KMT2APOLBL3MBTL1MEN1DUSP3 | |
| SCHEMBL15374273 | 0.71 | HIF1AN (0.56) | KMT2APOLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL8290392 | 0.71 | ITGB2 (0.39) | KMT2APOLBL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328105-B2 | Compounds and methods for regulating integrins | ADHAERE PHARMACEUTICALS, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-9023876-B2 | Compounds and methods for regulating integrins | ADHAERE PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20150105435-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRINS | ATEGRIN, INC. | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105435-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRINS | ITGA2, ITGB2, ITGA2B | KMT2A 2195/4885POLB 3373/4885L3MBTL1 2515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.