Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7523625 | 0.92 | CNR2 (0.44) | CNR2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7522346 | 0.84 | MAPT (0.51) | SMN1; SMN2MAPTTP53TRPV1ALOX5 | |
| SCHEMBL7522145 | 0.83 | FAAH (0.47) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL7529296 | 0.83 | LMNA (0.42) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL7523137 | 0.82 | FAAH (0.47) | SMN1; SMN2ALDH1A1KMT2ATHRBLMNA | |
| SCHEMBL16640905 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTTP53ALDH1A1KMT2A | |
| SCHEMBL7529468 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTKMT2ATHRBLMNA | |
| SCHEMBL7525688 | 0.81 | CCR2 (0.47) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL7529374 | 0.81 | PANK3 (0.42) | SMN1; SMN2MAPTTP53ALDH1A1ALOX5 | |
| SCHEMBL7525694 | 0.81 | TRPV1 (0.44) | CNR2SMN1; SMN2MAPTTRPV1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9416108-B2 | Heterocyclic aspartyl protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416108-B2 | Heterocyclic aspartyl protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150105354-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | US | disclosed |
| US-20150105354-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105354-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | PRSS1, BCHE, CTSZ | CNR2 2674/4885NPC1 700/4885RAB9A 2946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.