SCHEMBL1664326

SCHEMBL1664326

CCOc1ccc2oc(-c3ccccc3)c(OCC)c(=O)c2c1OCC

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 5/20 0.70
ACE2 Q9BYF1 1/20 0.52
PPARG P37231 1/20 0.49
ABCG2 Q9UNQ0 2/20 0.49
TP53 P04637 1/20 0.47
MAPT P10636 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
POLH Q9Y253 1/20 0.46
KCNA3 P22001 1/20 0.46
KMT2A Q03164 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ABCB1 P08183 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3710678 0.88 ADORA3 (0.65) ADORA3ACE2PPARGABCG2TP53
SCHEMBL16237121 0.88 ADORA3 (0.75) ADORA3ACE2PPARGABCG2MAPT
SCHEMBL3699175 0.87 ADORA3 (0.71) ADORA3ACE2PPARGABCG2KDM4E
SCHEMBL7548423 0.83 PPARG (0.63) ADORA3PPARGABCG2KDM4EGAA
SCHEMBL30741225 0.82 ADORA3 (1.00) ADORA3ACE2PPARGMAPTKDM4E
SCHEMBL1663784 0.82 ADORA3 (1.00) ADORA3ACE2PPARGMAPTKDM4E
SCHEMBL27677461 0.82 ADORA3 (0.48) ADORA3ACE2TP53MAPTRXFP1
SCHEMBL644478 0.81 MAOA (0.52) ADORA3ABCG2TP53MAPTRXFP1
SCHEMBL29833663 0.81 MAOA (0.52) ADORA3ABCG2TP53MAPTRXFP1
SCHEMBL7458770 0.80 ABCG2 (0.70) ADORA3ABCG2TP53MAPTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885192-B8 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) 2012-05-16 EP disclosed
EP-2311806-A2 Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists The United States of America, Represented by the Secretary, Department of Health and Human Services (US) 2011-04-20 EP disclosed
US-6066642-A FOR SELECTIVELY BLOCKING THE A3 ADENOSINE RECEPTOR OF A MAMMAL THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-05-23 US disclosed
EP-0885192-A1 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1998-12-23 EP disclosed
WO-1997027177-A2 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN-4-ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-07-31 WO disclosed