Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186948 | 0.89 | KMT2A (0.47) | KMT2AL3MBTL1NPSR1KDM4EMAPK1 | |
| SCHEMBL28137440 | 0.82 | TSHR (0.47) | KMT2AL3MBTL1GAANPSR1POLB | |
| SCHEMBL4752383 | 0.81 | KMT2A (0.42) | KMT2AL3MBTL1POLBKDM4ETSHR | |
| SCHEMBL7322996 | 0.80 | MMP9 (0.54) | KMT2AGAANPSR1KDM4ELMNA | |
| SCHEMBL27540668 | 0.78 | ALB (0.47) | KMT2AL3MBTL1TSHRALDH1A1MEN1 | |
| SCHEMBL647372 | 0.76 | KMT2A (1.00) | KMT2AL3MBTL1GAANPSR1POLB | |
| SCHEMBL7554619 | 0.75 | KMT2A (0.52) | KMT2AL3MBTL1GAANPSR1POLB | |
| SCHEMBL7550294 | 0.75 | KMT2A (0.52) | KMT2AL3MBTL1POLBCA1CA2 | |
| SCHEMBL27736140 | 0.75 | TSHR (0.53) | KMT2AL3MBTL1NPSR1POLBCA1 | |
| SCHEMBL2250340 | 0.72 | ALB (0.44) | KMT2AL3MBTL1GAAPOLBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |