Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 9/20 | 0.54 |
| ▸ | MMP13 | P45452 | 9/20 | 0.54 |
| ▸ | MMP1 | P03956 | 8/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27511019 | 0.94 | KEAP1 (0.57) | MMP9MMP13MMP1ADAM17CYP2C9 | |
| SCHEMBL7324037 | 0.88 | MMP9 (0.70) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7311624 | 0.88 | CYP2C9 (0.60) | MMP9MMP13MMP1ADAM17CYP2C9 | |
| SCHEMBL7323912 | 0.84 | MMP9 (0.65) | MMP9MMP13MMP1ADAM17CYP2C9 | |
| SCHEMBL7315173 | 0.84 | MMP9 (0.62) | MMP9MMP13MMP1ADAM17CYP2C9 | |
| SCHEMBL7311421 | 0.82 | MMP1 (0.81) | MMP9MMP13MMP1ADAM17CYP2C9 | |
| SCHEMBL7316361 | 0.80 | MMP9 (0.79) | MMP9MMP13MMP1ADAM17KEAP1 | |
| SCHEMBL166441 | 0.80 | KMT2A (0.61) | KDM4ELMNAGAANPSR1HSD17B10 | |
| SCHEMBL27511381 | 0.80 | MMP9 (0.69) | MMP9MMP13MMP1ADAM17PGR | |
| SCHEMBL7317778 | 0.78 | MMP13 (0.66) | MMP9MMP13MMP1ADAM17CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |