SCHEMBL16644757

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nearest known ligand 0.45

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	MMP13	P45452	2/20	0.45

▸	CD209	Q9NNX6	2/20	0.42

▸	FGF1	P05230	2/20	0.42

▸	VEGFA	P15692	2/20	0.42

▸	FGF2	P09038	1/20	0.42

▸	HPSE	Q9Y251	1/20	0.42

▸	SELP	P16109	3/20	0.41

▸	ALDH1A1	P00352	1/20	0.40

▸	CYP3A4	P08684	1/20	0.40

▸	ALOX15	P16050	1/20	0.40

▸	MAPK1	P28482	1/20	0.40

▸	HSD17B10	Q99714	1/20	0.40

▸	LGALS8	O00214	2/20	0.40

▸	LGALS3	P17931	2/20	0.40

▸	LGALS4	P56470	2/20	0.40

▸	SELL	P14151	2/20	0.39

▸	MDK	P21741	1/20	0.38

▸	ENGASE	Q8NFI3	1/20	0.38

▸	GJB2	P29033	1/20	0.37

▸	AMY2A	P04746	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18056147	1.00	MMP13 (0.45)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL16644846	1.00	MMP13 (0.45)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL16644789	1.00	MMP13 (0.45)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL16644766	0.98	MMP13 (0.47)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL18164176	0.98	MMP13 (0.47)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL16644765	0.98	MMP13 (0.47)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL18164248	0.98	MMP13 (0.47)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL16644812	0.98	MMP13 (0.47)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL16644781	0.96	MMP13 (0.47)	MMP13CD209FGF1VEGFAFGF2
SCHEMBL18056109	0.96	MMP13 (0.47)	MMP13CD209FGF1VEGFAFGF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20160303244-A1	GLUCOSE-RESPONSIVE INSULIN CONJUGATES	MERCK SHARP & DOHME CORP. (US)	2016-10-20	—	—	US	disclosed
WO-2016164288-A1	GLUCOSE-RESPONSIVE INSULIN CONJUGATES	MERCK SHARP & DOHME CORP. (US)	2016-10-13	—	—	WO	disclosed
US-20160251407-A1	GLUCOSE-RESPONSIVE INSULIN CONJUGATES	MERCK SHARP & DOHME CORP. (US)	2016-09-01	—	—	US	disclosed
US-9427475-B2	Glucose-responsive insulin conjugates	MERCK SHARP & DOHME CORP. (US)	2016-08-30	—	—	US	disclosed
US-20150105317-A1	GLUCOSE-RESPONSIVE INSULIN CONJUGATES	MERCK SHARP & DOHME LLC	2015-04-16	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20150105317-A1	GLUCOSE-RESPONSIVE INSULIN CONJUGATES	GPR119, INSR, IRS1	MMP13 3215/4885CD209 1933/4885FGF1 611/4885
US-20160251407-A1	GLUCOSE-RESPONSIVE INSULIN CONJUGATES	GPR119, INSR, IRS1	MMP13 3498/4885CD209 1805/4885FGF1 585/4885
US-20160303244-A1	GLUCOSE-RESPONSIVE INSULIN CONJUGATES	GPR119, INSR, IRS1	MMP13 3215/4885CD209 1933/4885FGF1 611/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.