Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.44 |
| ▸ | FGF1 | P05230 | 3/20 | 0.44 |
| ▸ | FGF2 | P09038 | 3/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | SELP | P16109 | 3/20 | 0.43 |
| ▸ | CD209 | Q9NNX6 | 2/20 | 0.41 |
| ▸ | MDK | P21741 | 1/20 | 0.40 |
| ▸ | GJB2 | P29033 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.39 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.39 |
| ▸ | LGALS4 | P56470 | 2/20 | 0.39 |
| ▸ | SELL | P14151 | 2/20 | 0.38 |
| ▸ | SELE | P16581 | 2/20 | 0.37 |
| ▸ | ENGASE | Q8NFI3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16644765 | 1.00 | MMP13 (0.47) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL16644766 | 1.00 | MMP13 (0.47) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL18164248 | 0.99 | MMP13 (0.47) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL16644812 | 0.99 | MMP13 (0.47) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL16644846 | 0.98 | MMP13 (0.45) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL18056147 | 0.98 | MMP13 (0.45) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL16644789 | 0.98 | MMP13 (0.45) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL16644757 | 0.98 | MMP13 (0.45) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL18056146 | 0.95 | MMP13 (0.46) | MMP13HPSEFGF1FGF2VEGFA | |
| SCHEMBL18056129 | 0.95 | MMP13 (0.43) | MMP13HPSEFGF1FGF2VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160303244-A1 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | GPR119, INSR, IRS1 | MMP13 3215/4885HPSE 875/4885FGF1 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.