Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 5/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.46 |
| ▸ | ESRRB | O95718 | 4/20 | 0.46 |
| ▸ | ESRRA | P11474 | 4/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653779 | 0.82 | ALDH1A1 (0.61) | RORCESR1ESR2ADORA1ADORA2A | |
| SCHEMBL3897673 | 0.80 | ADORA1 (0.54) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3907064 | 0.75 | PARP1 (0.42) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3906128 | 0.74 | DPP4 (0.43) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3901308 | 0.73 | DPP4 (0.44) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3893950 | 0.72 | ESRRB (0.41) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3895920 | 0.72 | ADORA1 (0.40) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3895581 | 0.72 | DPP4 (0.45) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3893249 | 0.71 | KDM4E (0.41) | ESR1ESR2ESRRBESRRAADORA1 | |
| SCHEMBL3896592 | 0.71 | DPP4 (0.46) | ESR1ESR2ESRRBESRRAADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160279122-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORgammat | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-29 | — | — | US | disclosed |
| US-9403816-B2 | Phenyl linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2016-08-02 | — | — | US | disclosed |
| US-20150105404-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279122-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORgammat | RORC, RORB, RORA | RORC 1/4885ESR1 1296/4885ESR2 427/4885 |
| US-20150105404-A1 | PHENYL LINKED QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | RORC 1/4885ESR1 1297/4885ESR2 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.