Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.71 |
| ▸ | CTSB | P07858 | 11/20 | 0.40 |
| ▸ | CTSS | P25774 | 10/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636023 | 0.90 | CTSK (0.76) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL18531328 | 0.89 | CTSK (0.73) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL18531329 | 0.88 | CTSK (0.72) | CTSKCTSBCTSSKCNH2CYP3A4 | |
| SCHEMBL16646013 | 0.88 | CTSK (0.67) | CTSKCTSBCTSSKCNH2CYP3A4 | |
| SCHEMBL16636259 | 0.87 | CTSK (0.78) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL16635893 | 0.86 | CTSK (0.79) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL16636039 | 0.86 | CTSK (0.76) | CTSKCTSBCTSSKCNH2CYP3A4 | |
| SCHEMBL16636126 | 0.86 | CTSK (0.80) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL16636021 | 0.84 | CTSK (0.68) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL16635994 | 0.84 | CTSK (0.80) | CTSKCTSBCTSSKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9573913-B2 | Cathepsin cysteine protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20160244417-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-25 | — | — | US | disclosed |
| WO-2015054038-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244417-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | CTSB, CTSS, CTSZ | CTSK 4/4885CTSB 1/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.