SCHEMBL7687629

SCHEMBL7687629

CCOC(=O)C1=C(C)NC(c2ccccc2)=C(C(=O)OCC)C1C

nearest known ligand 0.75

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 14/20 0.75
KDM4E B2RXH2 2/20 0.66
LMNA P02545 1/20 0.66
TMIGD3 P0DMS9 2/20 0.65
TRPV1 Q8NER1 3/20 0.64
ALDH1A1 P00352 2/20 0.64
CACNA1D Q01668 2/20 0.56
MEN1 O00255 1/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
XBP1 P17861 1/20 0.52
KMT2A Q03164 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7685244 0.93 ADORA3 (0.67) ADORA3KDM4ELMNATMIGD3TRPV1
SCHEMBL7689604 0.86 ADORA3 (0.65) ADORA3KDM4ELMNATMIGD3TRPV1
SCHEMBL7680777 0.86 ADORA3 (1.00) ADORA3TMIGD3TRPV1ALDH1A1CACNA1D
SCHEMBL1664685 0.85 ADORA3 (0.71) ADORA3KDM4ELMNATMIGD3TRPV1
SCHEMBL7685108 0.83 ADORA3 (0.74) ADORA3KDM4ETMIGD3TRPV1ALDH1A1
SCHEMBL7687307 0.81 ADORA3 (1.00) ADORA3TMIGD3TRPV1ALDH1A1CACNA1D
SCHEMBL3503405 0.81 KDM4E (1.00) KDM4ELMNAALDH1A1CACNA1DMEN1
SCHEMBL7386505 0.79 ADORA3 (0.56) ADORA3KDM4ELMNATMIGD3TRPV1
SCHEMBL13932305 0.79 ADORA3 (1.00) ADORA3KDM4ELMNATMIGD3TRPV1
SCHEMBL7383408 0.79 ALDH1A1 (0.57) ADORA3KDM4ETMIGD3TRPV1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US claimed
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US disclosed