Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665731 | 0.96 | LMNA (0.43) | EGFRRAB9ANPC1SMN1; SMN2USP2 | |
| SCHEMBL1664811 | 0.96 | LMNA (0.43) | EGFRRAB9ANPC1SMN1; SMN2USP2 | |
| SCHEMBL1665848 | 0.89 | PDE7A (0.40) | EGFRRAB9ANPC1SMN1; SMN2USP2 | |
| SCHEMBL17072271 | 0.88 | KMT2A (0.47) | EGFRRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1664624 | 0.87 | ALDH1A1 (0.46) | EGFRRAB9ANPC1SMN1; SMN2USP2 | |
| SCHEMBL1667332 | 0.86 | MAPT (0.48) | RAB9ANPC1SMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL1662766 | 0.86 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL1664440 | 0.86 | HPGDS (0.41) | EGFRRAB9ANPC1SMN1; SMN2USP2 | |
| SCHEMBL1664640 | 0.86 | ALDH1A1 (0.46) | EGFRRAB9ANPC1SMN1; SMN2USP2 | |
| SCHEMBL1665852 | 0.85 | NPC1 (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |